Asbestos, Lung Cancers, and Mesotheliomas

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Mesotheliomas--asbestos exposure and lung burden.

The assessment of asbestos fibres in the lungs at post mortem in groups of mesotheliomas, groups occupationally exposed to asbestos, and controls has shown that all these groups contain significant levels of asbestos as a lung burden. The amounts in each group are dependent on the degree of past exposure, being highest in those cases with a known or extrapolated occupational exposure, less in t...

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Mesotheliomas and asbestos type in asbestos textile workers: a study of lung contents.

The asbestos contents of the lungs of former employees of an asbestos textile factory were determined at necropsy using a transmission electron microscope. Those who had died of mesothelioma were compared with a matched sample of those who had died of other causes. The predominant fibre processed in the factory was chrysotile, but crocidolite had also been used. The lung content was consistent ...

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Environmental exposure to Libby Asbestos and mesotheliomas.

BACKGROUND Thirty-one cases of mesothelioma resulting from exposure to Libby Asbestos have been identified from Libby, Montana. Eleven cases not previously reported are the subject of this report. METHODS These cases are in non-occupationally exposed people, appearing to have resulted from exposure to contamination of the community, the surrounding forested area, and areas in proximity to the...

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Software for Apportionment of Asbestos-Related Mesotheliomas

Patients with an asbestos-related mesothelioma may be legally entitled to financial compensation. In this context, a physician may be called upon to apportion the contribution of an asbestos containing product or facility where there was asbestos exposure in the development of that individual's mesothelioma. This task is mathematically not simple. It is a complex function of each and the entire...

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Mutations of p53 gene and SV40 sequences in asbestos associated and non-asbestos-associated mesotheliomas.

AIM To examine mesotheliomas for a possible relation between p53 immunostaining, p53 gene mutation, simian virus 40 (SV40), and asbestos exposure. METHODS Paraffin sections from 11 mesotheliomas were used for p53 immunostaining and also to extract DNA. This was analysed for the presence of mutations in exons 5 to 8 of the p53 gene using a "cold" single strand conformational polymorphism metho...

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ژورنال

عنوان ژورنال: American Journal of Respiratory Cell and Molecular Biology

سال: 2010

ISSN: 1044-1549,1535-4989

DOI: 10.1165/rcmb.2009-0206tr